Week of October 5 - October 9, 2009 Tuesday, October 6, 2009 3:45 PM TENURED FACULTY MEETING 459 MSC Wednesday, October 7, 2009 3:30 PM Calculus Seminar 459 MSC Thomas Hern, BGSU Discussion on tangent lines and collapse metaphors (pp 409-413) Thursday, October 8, 2009 4:00 PM Advisory Committee Meeting 400 MSC Friday, October 9, 2009 3:30 PM COLLOQUIUM 459 MSC Dr. Nan Lin, Washington State University at St. Louis An information criterion for order-restricted inference and its application to clustering short time-course microarray data Abstract : Techniques of statistical inference under order restrictions have been successfully used in many areas in statistics. We consider the problem of selecting an order restriction profile out of a set of candidate profiles. Existing information criteria can only be used with simple ordering, such as monotone increasing or decreasing profiles. We developed a new information criterion for order-restricted inference applicable to general order restrictions, and showed its consistency in selecting the correct order restriction profile. This new information criterion is also successfully applied to clustering short time-course microarray data. We first define candidate gene clusters using the order restriction profile over the mean expression across time. A gene is then assigned to the best matched profile/cluster determined by our new information criterion. Compared to other existing clustering algorithms for short time-course microarray data, the information criterion-based clustering provides competitive clustering accuracy and is computationally more efficient.
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