Department of Mathematics and Statistics Calendar October 18 - 24, 2004 Monday, October 18, 2004 3:30 PM Graduate Student Seminar 400 MSc Juan MARIN, BGSU Tuesday, October 19, 2004 12:00 PM Advisory Committee Meeting 458 MSc 3:30 PM Calculus Seminar 459 MSc Hope BARBERA and Mary KOSHAR, BGSU TOPIC: The new projector and some Maple demos 5:00 PM Honors MATH 295 Seminar 459 MSc Professor Gábor J. SZÉKELY, BGSU "The Book of Beautiful Proofs" Wednesday, October 20, 2004 3:30 PM Statistics Seminar 445 MSc Dr. Jane Y. CHANG, BGSU, Dept. of ASOR "Designing NimbleGen Microarrays for Statistical Analysis of Gene Expressions" ABSTRACT: Genes code for protein. Every living cell has a full complement of all the genes. Microarrays can measure, en masse, the extent to which various genes are turned on (called gene expressions) in sample cells. With all the hype about bioinformatics, one might wonder to what extent society has benefited from microarray research. Applications are imminent, in the form of prognostic/diagnostic chips and patient subgroup targeting based on gene expression profiling. In the past, approval of medical devices and drugs by FDA have required statistical validation. Whether there will be such requirements for microarray applications will be seen shortly. One impediment is the inconvenience of randomly placing gene probes on microarrays. The most popular microarrays made by market leader Affymetrix neither randomize nor replicate the gene probes on oligonucleotide microarrays. Randomization and replication are necessarily for the validity of statistical analyses. In the presentation, I will report on a joint project with Professor Jason Hsu at Ohio State, Iceland Genomics Corp., the National Hospital of Iceland, and NimbleGen systems. We have statistically designed microarrays with randomization, replication, and blocking to not only find differentially expressed genes between low and high risk patients, but also assess sensitivity and specificity of the microarrays. With samples from Iceland Genomics Corp., clinical outcomes from the National Hospital of Iceland, and microarrays made by NimbleGen, we hope to prove the concept that microarray applications can meet rigorous statistical requirements. Thursday, October 21, 2004 1:30 PM Algebra Seminar 459 MSc Michelle KNOX, BGSU 4:00 PM Research Areas Seminar 459 MSc Dr. Warren Wm. McGOVERN, BGSU "Clean Rings" Friday, October 22, 2004 Last day to Withdraw Pass (with a signature) from classes 12:00 PM - 9:00 PM Ohio Section MAA Meeting John Carroll University for the complete program, see: http://www.jcu.edu/math/maa/ **12:00 PM Calendar Information due to Cyndi for inclusion in next week's calendar listing** 3:30 PM Refreshment Served for Colloquium 459 MSc 3:45 PM Colloquium Talk Begins 459 MSc Dr. Daniel MIHALKO, Western Michigan University "On Similarity Indices for Comparing Clustering Results" ABSTRACT: Many similarity indices have been introduced in the literature for comparing the results of different clusterings of the same data set. This work shows that after correction for chance agreement, many of these indices are actually equivalent. Potential uses of similarity indices in the analysis of gene expression experiments will also be discussed. Saturday, October 23, 2004 8:00 AM - 1:00 PM Ohio Section MAA Meeting continues @ John Carroll University for program see: http://www.jcu.edu/math/maa/ Sunday, October 24, 2004
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