Department of Mathematics and Statistics Calendar
October 18 - 24, 2004
Monday, October 18, 2004
3:30 PM Graduate Student Seminar 400 MSc
Juan MARIN, BGSU
Tuesday, October 19, 2004
12:00 PM Advisory Committee Meeting 458 MSc
3:30 PM Calculus Seminar 459 MSc
Hope BARBERA and Mary KOSHAR, BGSU
TOPIC: The new projector and some Maple demos
5:00 PM Honors MATH 295 Seminar 459 MSc
Professor Gábor J. SZÉKELY, BGSU
"The Book of Beautiful Proofs"
Wednesday, October 20, 2004
3:30 PM Statistics Seminar 445 MSc
Dr. Jane Y. CHANG, BGSU, Dept. of ASOR
"Designing NimbleGen Microarrays for Statistical
Analysis of Gene Expressions"
ABSTRACT: Genes code for protein. Every living cell has a
full complement of all the genes. Microarrays can measure,
en masse, the extent to which various genes are turned on (called
gene expressions) in sample cells.
With all the hype about bioinformatics, one might wonder to
what extent society has benefited from microarray research.
Applications are imminent, in the form of prognostic/diagnostic
chips and patient subgroup targeting based on gene expression
profiling.
In the past, approval of medical devices and drugs by FDA
have required statistical validation. Whether there will be such
requirements for microarray applications will be seen shortly. One
impediment is the inconvenience of randomly placing gene probes on
microarrays. The most popular microarrays made by market leader
Affymetrix neither randomize nor replicate the gene probes on
oligonucleotide microarrays. Randomization and replication are
necessarily for the validity of statistical analyses.
In the presentation, I will report on a joint project with
Professor Jason Hsu at Ohio State, Iceland Genomics Corp., the
National Hospital of Iceland, and NimbleGen systems. We have
statistically designed microarrays with randomization, replication,
and blocking to not only find differentially expressed genes between
low and high risk patients, but also assess sensitivity and
specificity of the microarrays. With samples from Iceland Genomics
Corp., clinical outcomes from the National Hospital of Iceland, and
microarrays made by NimbleGen, we hope to prove the concept that
microarray applications can meet rigorous statistical requirements.
Thursday, October 21, 2004
1:30 PM Algebra Seminar 459 MSc
Michelle KNOX, BGSU
4:00 PM Research Areas Seminar 459 MSc
Dr. Warren Wm. McGOVERN, BGSU
"Clean Rings"
Friday, October 22, 2004
Last day to Withdraw Pass (with a signature) from classes
12:00 PM - 9:00 PM Ohio Section MAA Meeting
John Carroll University
for the complete program, see:
http://www.jcu.edu/math/maa/
**12:00 PM Calendar Information due to Cyndi
for inclusion in next week's calendar listing**
3:30 PM Refreshment Served for Colloquium 459 MSc
3:45 PM Colloquium Talk Begins 459 MSc
Dr. Daniel MIHALKO, Western Michigan University
"On Similarity Indices for Comparing Clustering Results"
ABSTRACT: Many similarity indices have been introduced in the
literature for comparing the results of different clusterings of the
same data set. This work shows that after correction for chance
agreement, many of these indices are actually equivalent. Potential
uses of similarity indices in the analysis of gene expression
experiments will also be discussed.
Saturday, October 23, 2004
8:00 AM - 1:00 PM Ohio Section MAA Meeting continues
@ John Carroll University
for program see: http://www.jcu.edu/math/maa/
Sunday, October 24, 2004
A list of mathematics seminars by subject and other seminars at BGSU is available here.
If you have comments or material for the calendar, send e-mail to Cyndi
Patterson,
If you wish to be placed on the e-mail
distribution list, send e-mail
to Craig Zirbel,
Previous calendars are available individually
or in one single file for searching.
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